Search results for "C3 polymorphism"

showing 2 items of 2 documents

C3 reference typing report and nomenclature revision.

1990

As the result of reference typing, two 'new' variants could be provisionally accepted (C3F045 and C3F015). The list of variants of the C3 polymorphism includes now 2 common and 29 rare variants.

Polymorphism GeneticEvolutionary biologyReference ValuesC3 polymorphismTerminology as TopicImmunologyGenetic VariationHumansHematologyTypingComplement C3BiologyNomenclatureComplement and inflammation
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Reference Typing Reportfor Complement Component C3

1998

A comparison of five C3 variant samples has been performed by conventional high-voltage gel electrophoresis in three laboratories (Palermo, Berlin and Mainz). Local designation was shown within SD = ±0.75 mm migration distance in the Mainz laboratory. Methodological modifications by laboratories were not accounted for (cooling temperature, relative mobilities between runs). In parallel, all reference samples were also sequenced after exon-specific amplification. As a result, two variants with identical final designations and two variants with different mobilities were shown to conform at the molecular basis exhibiting an amino acid exchange that causes the corresponding change in relative m…

Gel electrophoresisChemistryComponent (thermodynamics)C3 polymorphismCooling temperatureImmunologyAnalytical chemistryMolecular biologyhumanitiesBlood protein electrophoresisGeneticsTypingReference standardsGenetics (clinical)Complement (set theory)Experimental and Clinical Immunogenetics
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